Journal
GENESIS
Volume 47, Issue 9, Pages 611-616Publisher
WILEY
DOI: 10.1002/dvg.20541
Keywords
histone modification; variant histone; genomic imprinting; preimplantation development; mouse
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Funding
- MEXT
- JSPS
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Allele-specific association of histone modification is observed at the regulatory region of imprinted genes and has been suggested to work as an epigenetic marker for monoallelic gene expression, along with the allelic CpG methylation of DNA. Although the parent-origin-specific epigenetic status in imprinted genes is thought to be established during preimplantation development, little is known about the allelic specificity of histone modifications during this period because of the limited volume of material available for analysis. In this study, we first revealed the allelic enrichment of histone modifications and variant histories at the imprinting control regions (ICRs) of four-cell to blastocyst stage preimplantation embryos by using carrier chromatin immunoprecipitation and sequence polymorphism analysis of immunoprecipitated DNA. We found relative enrichment of histone H3 lysine 9 dimethylation at the imprinted alleles of ICRs and obtained the results suggesting that histone modifications at ICRs are established during a late preimplantation stage. genesis 47:611-616, 2009. (C) 2009 Wiley-Liss, Inc.
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