Journal
GENESIS
Volume 46, Issue 6, Pages 324-328Publisher
WILEY
DOI: 10.1002/dvg.20399
Keywords
ocular lens; skeletal muscles; Cre recombinase; Pitx3; BAC transgene
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To generate temporally controlled inactivation or activation of interested genes in Pitx3-expressing cells, the tamoxifen-inducible form of Cre, CreER(T2), was inserted into the Pitx3 locus of a mouse BAC clone. Following a single dose of tamoxifen, Cre activity in Pitx3-CreER(T2) transgenic mice was observed in the ocular lens and skeletal muscles but not in the central nervous system at various embryonic stages. This mouse line provides a reagent for driving inducible Cre-dependent recombination in the lens and skeletal muscles during embryonic development.
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