Journal
GENES TO CELLS
Volume 20, Issue 1, Pages 29-35Publisher
WILEY-BLACKWELL
DOI: 10.1111/gtc.12194
Keywords
-
Categories
Funding
- CREST grant from the Japan Science and Technology Agency
- Ministry of Education, Culture, Sports, Science and Technology in Japan
Ask authors/readers for more resources
In multicellular organisms, cell properties, such as shape, size and function are important in morphogenesis and physiological functions. Recently, cellular chirality' has attracted attention as a cellular property because it can cause asymmetry in the bodies of animals. In recent in vitro studies, the left-right bias of cellular migration and of autonomous arrangement of cells under some specific culture conditions were discovered. However, it is difficult to identify the molecular mechanism underlying their intrinsic chirality because the left-right bias observed to date is subtle or is manifested in the stable orientation of cells. Here, we report that zebrafish (Danio rerio) melanophores exhibit clear cellular chirality by unidirectional counterclockwise rotational movement under isolated conditions without any special settings. The chirality is intrinsic to melanophores because the direction of the cellular rotation was not affected by the type of extracellular matrix. We further found that the cellular rotation was generated as a counter action of the clockwise movement of actin cytoskeleton. It suggested that the mechanism that directs actin cytoskeleton in the clockwise direction is pivotal for determining cellular chirality.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available