4.2 Review

Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution

Related references

Note: Only part of the references are listed.
Review Biochemistry & Molecular Biology

Physiological significance of selective degradation of p62 by autophagy

Masaaki Komatsu et al.

FEBS LETTERS (2010)

Article Biochemistry & Molecular Biology

Physical and Functional Interaction of Sequestosome 1 with Keap1 Regulates the Keap1-Nrf2 Cell Defense Pathway

Ian M. Copple et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Article Biochemistry & Molecular Biology

The Critical Role of Nitric Oxide Signaling, via Protein S-Guanylation and Nitrated Cyclic GMP, in the Antioxidant Adaptive Response

Shigemoto Fujii et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Article Oncology

Oncogenic NRF2 mutations in squamous cell carcinomas of oesophagus and skin

Yoo Ri Kim et al.

JOURNAL OF PATHOLOGY (2010)

Article Biochemistry & Molecular Biology

Genetic Analysis of Cytoprotective Functions Supported by Graded Expression of Keap1

Keiko Taguchi et al.

MOLECULAR AND CELLULAR BIOLOGY (2010)

Article Biochemistry & Molecular Biology

A Noncanonical Mechanism of Nrf2 Activation by Autophagy Deficiency: Direct Interaction between Keap1 and p62

Alexandria Lau et al.

MOLECULAR AND CELLULAR BIOLOGY (2010)

Article Multidisciplinary Sciences

Keap1 is a forked-stem dimer structure with two large spheres enclosing the intervening, double glycine repeat, and C-terminal domains

Toshihiko Ogura et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Pharmacology & Pharmacy

Cysteine-based regulation of the CUL3 adaptor protein Keap1

Konjeti R. Sekhar et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2010)

Article Oncology

Nrf2 Enhances Cell Proliferation and Resistance to Anticancer Drugs in Human Lung Cancer

Shinsuke Homma et al.

CLINICAL CANCER RESEARCH (2009)

Article Biochemistry & Molecular Biology

The Antioxidant Defense System Keap1-Nrf2 Comprises a Multiple Sensing Mechanism for Responding to a Wide Range of Chemical Compounds

Makoto Kobayashi et al.

MOLECULAR AND CELLULAR BIOLOGY (2009)

Article Biochemistry & Molecular Biology

Direct Interaction between Nrf2 and p21Cip1/WAF1 Upregulates the Nrf2-Mediated Antioxidant Response

Weimin Chen et al.

MOLECULAR CELL (2009)

Article Multidisciplinary Sciences

Targeting Nrf2 with the triterpenoid CDDO-imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice

Thomas E. Sussan et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Biochemistry & Molecular Biology

Comprehensive proteomics analysis of autophagy-deficient mouse liver

Naomi Matsumoto et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2008)

Article Biochemistry & Molecular Biology

Hypermethylation of the Keap1 gene in human lung cancer cell lines and lung cancer tissues

Rui Wang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2008)

Review Biochemistry & Molecular Biology

Mallory-Denk-bodies: Lessons from keratin-containing hepatic inclusion bodies

R. Strnad et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2008)

Article Chemistry, Medicinal

Prospective Type 1 and Type 2 Disulfides of Keap1 Protein

Ryan Holland et al.

CHEMICAL RESEARCH IN TOXICOLOGY (2008)

Article Chemistry, Medicinal

Covalent modification at Cys151 dissociates the electrophile sensor Keap1 from the ubiquitin ligase CUL3

Girish Rachakonda et al.

CHEMICAL RESEARCH IN TOXICOLOGY (2008)

Article Instruments & Instrumentation

Structural insights into the similar modes of Nrf2 transcription factor recognition by the cytoplasmic repressor Keap1

Balasundaram Padmanabhan et al.

JOURNAL OF SYNCHROTRON RADIATION (2008)

Article Biochemistry & Molecular Biology

Physiological significance of reactive cysteine residues of keap1 in determining Nrf2 activity

Tae Yamamoto et al.

MOLECULAR AND CELLULAR BIOLOGY (2008)

Article Biotechnology & Applied Microbiology

Treatment of arthritis with a selective inhibitor of c-Fos/activator protein-1

Yukihiko Aikawa et al.

NATURE BIOTECHNOLOGY (2008)

Article Multidisciplinary Sciences

Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy

Tatsuhiro Shibata et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Biochemistry & Molecular Biology

Molecular evolution of Keap1 - Two Keap1 molecules with distinctive intervening region structures are conserved among fish

Li Li et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Article Biochemistry & Molecular Biology

A mutation of Keap1 found in breast cancer impairs its ability to repress Nrf2 activity

Paul Nioi et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)

Article Biochemistry & Molecular Biology

Different electrostatic Potentials define ETGE and DLG motifs as hinge and latch in oxidative stress response

Kit I. Tong et al.

MOLECULAR AND CELLULAR BIOLOGY (2007)

Article Biochemistry & Molecular Biology

Protein S-guanylation by the biological signal 8-nitroguanosine 3′,5′-cyclic monophosphate

Tomohiro Sawa et al.

NATURE CHEMICAL BIOLOGY (2007)

Article Biochemistry & Molecular Biology

Molecular mechanism of human Nrf2 activation and degradation: Role of sequential phosphorylation by protein kinase CK2

Jingbo Pi et al.

FREE RADICAL BIOLOGY AND MEDICINE (2007)

Review Oncology

From Mallory to Mallory-Denk bodies: what, how and why?

Kurt Zatloukal et al.

EXPERIMENTAL CELL RESEARCH (2007)

Article Multidisciplinary Sciences

Dioxin receptor is a ligand-dependent E3 ubiquitin ligase

Fumiaki Ohtake et al.

NATURE (2007)

Article Biochemistry & Molecular Biology

Two-site substrate recognition model for the Keap1-Nrf2 system: a hinge and latch mechanism

Kit I. Tong et al.

BIOLOGICAL CHEMISTRY (2006)

Article Medicine, General & Internal

Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer

Anju Singh et al.

PLOS MEDICINE (2006)

Article Biochemistry & Molecular Biology

Phosphorylation of tyrosine 568 controls nuclear export of Nrf2

AK Jain et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Article Biochemistry & Molecular Biology

Keap1 recruits Neh2 through binding to ETGE and DLG motifs: Characterization of the two-site molecular recognition model

KI Tong et al.

MOLECULAR AND CELLULAR BIOLOGY (2006)

Article Biochemistry & Molecular Biology

Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer

B Padmanabhan et al.

MOLECULAR CELL (2006)

Article Biochemistry & Molecular Biology

Hepatocyte-specific deletion of the keap1 gene activates Nrf2 and confers potent resistance against acute drug toxicity

H Okawa et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2006)

Article Biochemistry & Molecular Biology

Oxidative and electophilic stresses activate Nrf2 through inhibition of ubiquitination activity if Keap1

A Kobayashi et al.

MOLECULAR AND CELLULAR BIOLOGY (2006)

Article Biochemistry & Molecular Biology

Specific patterns of electrophile adduction trigger Keap1 ubiquitination and Nrf2 activation

F Hong et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Article Multidisciplinary Sciences

Modifying specific cysteines of the electrophile-sensing human Keap1 disrupt binding to the protein is insufficient to Nrf2 domain Neh2

AL Eggler et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Biochemistry & Molecular Biology

Evolutionary conserved N-terminal domain of Nrf2 is essential for the Keap1-mediated degradation of the protein by proteasome

Y Katoh et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2005)

Review Biochemistry & Molecular Biology

Redox activation of p21(Cip1/WAF1/Sdi1): A multifunctional regulator of cell survival and death

MA O'Reilly

ANTIOXIDANTS & REDOX SIGNALING (2005)

Article Biochemistry & Molecular Biology

BTB protein keap1 targets antioxidant transcription factor nrf2 for ubiquitination by the cullin 3-Roc1 ligase

M Furukawa et al.

MOLECULAR AND CELLULAR BIOLOGY (2005)

Article Multidisciplinary Sciences

Protection against electrophile and oxidant stress by induction of the phase 2 response: Fate of cysteines of the Keap1 sensor modified by inducers

N Wakabayashi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Article Biochemistry & Molecular Biology

The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: Oxidative stress sensing by a Cul3-Keap1 ligase

SB Cullinan et al.

MOLECULAR AND CELLULAR BIOLOGY (2004)

Article Biochemistry & Molecular Biology

Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate for proteasomal degradation of Nrf2

A Kobayashi et al.

MOLECULAR AND CELLULAR BIOLOGY (2004)

Article Biochemistry & Molecular Biology

Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex

DD Zhang et al.

MOLECULAR AND CELLULAR BIOLOGY (2004)

Review Biochemistry & Molecular Biology

Nrf2-Keap1 defines a physiologically important stress response mechanism

H Motohashi et al.

TRENDS IN MOLECULAR MEDICINE (2004)

Review Urology & Nephrology

von Hippel-Lindau tumor suppressor protein and hypoxia-inducible factor in kidney cancer

MA Maynard et al.

AMERICAN JOURNAL OF NEPHROLOGY (2004)

Review Biochemistry & Molecular Biology

Molecular mechanism activating Nrf2-Keap1 pathway in regulation of adaptive response to electrophiles

K Itoh et al.

FREE RADICAL BIOLOGY AND MEDICINE (2004)

Article Cell Biology

Atypical protein kinase C mediates activation of NF-E2-related factor 2 in response to oxidative stress

S Numazawa et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2003)

Article Genetics & Heredity

Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation

N Wakabayashi et al.

NATURE GENETICS (2003)

Article Biochemistry & Molecular Biology

Phosphorylation of Nrf2 at Ser-40 by protein kinase C regulates antioxidant response element-mediated transcription

HC Huang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

Article Multidisciplinary Sciences

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

AT Dinkova-Kostova et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)

Article Urology & Nephrology

Nrf2-deficient female mice develop lupus-like autoimmune nephritis

K Yoh et al.

KIDNEY INTERNATIONAL (2001)

Article Multidisciplinary Sciences

Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice

M Ramos-Gomez et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)

Review Biochemistry & Molecular Biology

The chemical diversity and distribution of glucosinolates and isothiocyanates among plants

JW Fahey et al.

PHYTOCHEMISTRY (2001)

Review Cell Biology

The kelch repeat superfamily of proteins: propellers of cell function

J Adams et al.

TRENDS IN CELL BIOLOGY (2000)