Related references
Note: Only part of the references are listed.The BCL11B tumor suppressor is mutated across the major molecular subtypes of T-cell acute lymphoblastic leukemia
Alejandro Gutierrez et al.
BLOOD (2011)
Molecular pathogenesis and targeted therapies for NOTCH1-induced T-cell acute lymphoblastic leukemia
Maddalena Paganin et al.
BLOOD REVIEWS (2011)
Oncogenic activation of the Notch1 gene by deletion of its promoter in Ikaros-deficient T-ALL
Robin Jeannet et al.
BLOOD (2010)
Deletion-based mechanisms of Notch1 activation in T-ALL: key roles for RAG recombinase and a conserved internal translational start site in Notch1
Todd D. Ashworth et al.
BLOOD (2010)
The In Vivo Pattern of Binding of RAG1 and RAG2 to Antigen Receptor Loci
Yanhong Ji et al.
CELL (2010)
An Early T Cell Lineage Commitment Checkpoint Dependent on the Transcription Factor Bcl11b
Long Li et al.
SCIENCE (2010)
An Essential Developmental Checkpoint for Production of the T Cell Lineage
Tomokatsu Ikawa et al.
SCIENCE (2010)
Identification and molecular characterization of recurrent genomic deletions on 7p12 in the IKZF1 gene in a large cohort of BCR-ABL1-positive acute lymphoblastic leukemia patients: on behalf of Gruppo Italiano Malattie Ematologiche dell'Adulto Acute Leukemia Working Party (GIMEMAALWP)
Ilaria Iacobucci et al.
BLOOD (2009)
IKZF1 (Ikaros) Deletions in BCR-ABL1-Positive Acute Lymphoblastic Leukemia Are Associated With Short Disease-Free Survival and High Rate of Cumulative Incidence of Relapse: A GIMEMA AL WP Report
Giovanni Martinelli et al.
JOURNAL OF CLINICAL ONCOLOGY (2009)
Rag-dependent and Rag-independent mechanisms of Notch1 rearrangement in thymic lymphomas of Atm-/- and scid mice
Hideo Tsuji et al.
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2009)
Deletion of IKZF1 and Prognosis in Acute Lymphoblastic Leukemia.
Charles G. Mullighan et al.
NEW ENGLAND JOURNAL OF MEDICINE (2009)
The role of NOTCH1 signaling in T-ALL
A. A. Ferrando
Hematology-American Society of Hematology Education Program (2009)
Notch signaling in leukemia
Jon C. Aster et al.
ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE (2008)
Failure of CDKN2A/B (INK4A/B-ARF)-mediated tumor suppression and resistance to targeted therapy in acute lymphoblastic leukemia induced by BCR-ABL
Charles G. Mullighan et al.
GENES & DEVELOPMENT (2008)
V(D)J recombinase binding and cleavage of cryptic recombination signal sequences identified from lymphoid malignancies
Ming Zhang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Leukemia-associated NOTCH1 alleles are weak tumor initiators but accelerate K-ras-initiated leukemia
Mark Y. Chiang et al.
JOURNAL OF CLINICAL INVESTIGATION (2008)
BCR-ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros
Charles G. Mullighan et al.
NATURE (2008)
The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia
Benjamin J. Thompson et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2007)
Regulation of lymphocyte development by Notch signaling
Kenji Tanigaki et al.
NATURE IMMUNOLOGY (2007)
Haploinsufficiency of Bcl11b for suppression of lymphomagenesis and thymocyte development
Kenya Kamimura et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)
Activation of TLX3 and NKX2-5 in t(5;14)(q35;q32) T-cell acute lymphoblastic leukemia by remote 3'-BCL11B enhancers and coregulation by PU.1 and HMGA1
Stefan Nagel et al.
CANCER RESEARCH (2007)
Roles of nonhomologous DNA end joining, V(D)J recombination, and class switch recombination in chromosomal translocations
Michael R. Lieber et al.
DNA REPAIR (2006)
Recombinase, chromosomal translocations and lymphoid neoplasia:: Targeting mistakes and repair failures
Rodrig Marculescu et al.
DNA REPAIR (2006)
Early hematopoietic lineage restrictions directed by Ikaros
T Yoshida et al.
NATURE IMMUNOLOGY (2006)
Notch1 mutations are important for leukemic transformation in murine models of precursor-T leukemia/lymphoma
YW Lin et al.
BLOOD (2006)
BCR-ABL1 induces aberrant splicing of IKAROS and lineage infidelity in pre-B lymphoblastic leukemia cells
F Klein et al.
ONCOGENE (2006)
Notch activation is an early and critical event during T-cell leukemogenesis in Ikaros-deficient mice
A Dumortier et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
Aberrant methylation of p14ARF, p15INK4b and p16INK4a genes and location of the primary site in pulmonary squamous cell carcinoma
O Furonaka et al.
PATHOLOGY INTERNATIONAL (2004)
Involvement of illegitimate V(D)J recombination or microhomology-mediated nonhomologous end-joining in the formation of intragenic deletions of the Notch1 gene in mouse thymic lymphomas
H Tsuji et al.
CANCER RESEARCH (2004)
Involvement of V(D)J recombinase in the generation of intragenic deletions in the Rit1/Bcl11b tumor suppressor gene in γ-ray-induced thymic lymphomas and in normal thymus of the mouse
J Sakata et al.
CARCINOGENESIS (2004)
Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia
AP Weng et al.
SCIENCE (2004)
Radiation-induced deletions in the 5′ end region of Notch1 lead to the formation of truncated proteins and are involved in the development of mouse thymic lymphomas
H Tsuji et al.
CARCINOGENESIS (2003)
Bcl11b is required for differentiation and survival of αβ T lymphocytes
Y Wakabayashi et al.
NATURE IMMUNOLOGY (2003)
Ikaros, aiolos and helios: Transcription regulators and lymphoid malignancies
A Rebollo et al.
IMMUNOLOGY AND CELL BIOLOGY (2003)
Prevalent involvement of illegitimate V(D)J recombination in chromosome 9p21 deletions in lymphoid leukemia
Y Kitagawa et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
HPRT mutations in humans:: biomarkers for mechanistic studies
RJ Albertini
MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH (2001)
Mechanisms of chromosomal translocations in B cell lymphomas
R Küppers et al.
ONCOGENE (2001)
Analysis of the V(D)J recombination efficiency at lymphoid chromosomal translocation breakpoints
SC Raghavan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
SCL and LMOI alter thymocyte differentiation:: inhibition of E2A-HEB function and pre-Tα chain expression
S Herblot et al.
NATURE IMMUNOLOGY (2000)
Share Paper
