Journal
GENES BRAIN AND BEHAVIOR
Volume 7, Issue -, Pages 1-5Publisher
WILEY
DOI: 10.1111/j.1601-183X.2007.00373.x
Keywords
Alzheimer's disease; amyloid; APP; axonal transport; intracellular A beta; motor impairment; tau
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In this commentary, we accent the accumulating evidence for motor impairment as a common feature of early Alzheimer's disease (AD) pathology. In addition, we summarize the state of knowledge on this phenotype in experimental mouse models, expressing AD-associated genes like tau or amyloid precursor protein.
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