Journal
GENES BRAIN AND BEHAVIOR
Volume 7, Issue 6, Pages 669-676Publisher
WILEY
DOI: 10.1111/j.1601-183X.2008.00404.x
Keywords
AEX-3; ethanol consumption; ethanol resistance; neurotransmitter release; presynaptic; RAB-3/RAB3A
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Funding
- NIAAA NIH HHS [R01 AA013417, R01 AA016837, R01 AA010035, P20 AA017828, R01 AA016842] Funding Source: Medline
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The mechanisms by which ethanol induces changes in behavior are not well understood. Here, we show that Caenorhabditis elegans loss-of-function mutations in the synaptic vesicle-associated RAB-3 protein and its guanosine triphosphate exchange factor AEX-3 confer resistance to the acute locomotor effects of ethanol. Similarly, mice lacking one or both copies of Rab3A are resistant to the ataxic and sedative effects of ethanol, and Rab3A haploinsufficiency increases voluntary ethanol consumption. These data suggest a conserved role of RAB-3-/RAB3A-regulated neurotransmitter release in ethanol-related behaviors.
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