Journal
GENES AND NUTRITION
Volume 3, Issue 1, Pages 29-34Publisher
BMC
DOI: 10.1007/s12263-008-0076-3
Keywords
angiogenesis; anti-angiogenesis; metastasis; microenvironment; multiple myeloma; tumor growth
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Funding
- Associazione Italiana per la Ricerca sul Cancro Funding Source: Custom
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Tumor microenvironment is essential for tumor cell proliferation, angiogenesis, invasion and metastasis through its provision of survival signals, secretion of growth and pro-angiogenic factors, and direct adhesion molecule interactions. This review examines its importance in the induction of an angiogenic response in tumors and in multiple myeloma. The encouraging results of pre-clinical and clinical trials in which tumors have been treated by targeting the tumor microenvironment are also discussed.
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