Journal
GENES AND IMMUNITY
Volume 14, Issue 3, Pages 187-191Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/gene.2013.2
Keywords
PheWAS; HLA-DRB1; benign neoplasm; alcohol abuse; rosacea; multiple sclerosis
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Funding
- NLM grant [5T15LM007359]
- NIGMS grant [R01GM097618]
- NCATS grant [UL1TR000427]
- NCRR grant [1U1RR025011]
- Marshfield Clinic Research Foundation through the Personalized Medicine Research Project
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HLA-DRB1 codes for a major histocompatibility complex class II cell surface receptor. Genetic variants in and around this gene have been linked to numerous autoimmune diseases. Most notably, an association between HLA-DRB1*1501 haplotype and multiple sclerosis (MS) has been defined. Utilizing electronic health records and 4235 individuals within Marshfield Clinic's Personalized Medicine Research Project, a reverse genetic screen coined phenome-wide association study (PheWAS) tested association of rs3135388 genotype (tagging HLA-DRB1*1501) with 4841 phenotypes. As expected, HLA-DRB1*1501 was associated with MS (International Classification of Disease version 9-CM (ICD9) 340, P = 0.023), whereas the strongest association was with alcohol-induced cirrhosis of the liver (ICD9 571.2, P = 0.00011). HLA-DRB1*1501 also demonstrated association with erythematous conditions (ICD9 695, P = 0.0054) and benign neoplasms of the respiratory and intrathoracic organs (ICD9 212, P = 0.042), replicating previous findings. This study not only builds on the feasibility/utility of the PheWAS approach, represents the first external validation of a PheWAS, but may also demonstrate the complex etiologies associated with the HLA-DRB1*1501 loci. Genes and Immunity (2013) 14, 187-191; doi:10.1038/gene.2013.2; published online 7 February 2013
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