Journal
GENES & DEVELOPMENT
Volume 28, Issue 14, Pages 1544-1549Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.244350.114
Keywords
DNA methylation; piRNA; retrotransposon; germ cells; LINE; LTR
Categories
Funding
- National Institutes of Health (NIH) [5RC2HD064459-01]
- NIH [HG006015]
- [R37GM062534]
- Cancer Research UK [21143] Funding Source: researchfish
Ask authors/readers for more resources
During development, mammalian germ cells reprogram their epigenomes via a genome-wide erasure and de novo rewriting of DNA methylation marks. We know little of how methylation patterns are specifically determined. The piRNA pathway is thought to target the bulk of retrotransposon methylation. Here we show that most retrotransposon sequences are modified by default de novo methylation. However, potentially active retrotransposon copies evade this initial wave, likely mimicking features of protein-coding genes. These elements remain transcriptionally active and become targets of piRNA-mediated methylation. Thus, we posit that these two waves play essential roles in resetting germ cell epigenomes at each generation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available