Journal
GENES & DEVELOPMENT
Volume 28, Issue 2, Pages 121-126Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.230599.113
Keywords
lipin; endoplasmic reticulum; phospholipid synthesis; phosphatidylinositol
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Funding
- A.P. Giannini Foundation
- Hartwell Foundation
- Ludwig Institute for Cancer Research
- Deutsche Forschungsgemeinschaft [MU 1423/3-2, MU 1423/4-1]
- Human Frontier Science Program [RGP 0034/2010]
- NIH [DK18024, DK18849, GM088151]
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The nuclear envelope is a subdomain of the endoplasmic reticulum (ER). Here we characterize CNEP-1 (CTD [Cterminal domain] nuclear envelope phosphatase-1), a nuclear envelope-enriched activator of the ER-associated phosphatidic acid phosphatase lipin that promotes synthesis of major membrane phospholipids over phosphatidylinositol (PI). CNEP-1 inhibition led to ectopic ER sheets in the vicinity of the nucleus that encased the nuclear envelope and interfered with nuclear envelope breakdown (NEBD) during cell division. Reducing PI synthesis suppressed these phenotypes, indicating that CNEP-1 spatially regulates phospholipid flux, biasing it away from PI production in the vicinity of the nuclear envelope to prevent excess ER sheet formation and NEBD defects.
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