Journal
GENES & DEVELOPMENT
Volume 27, Issue 19, Pages 2065-2071Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.228122.113
Keywords
Ras; macropinocytosis; autophagy; cancer metabolism; glutamine; scavenging
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Funding
- NIH [R01CA163591, RO1CA130893]
- Department of Defense [W81XWH-09-01-0394]
- Val Skinner Foundation
- New Jersey Commission for Cancer Research
- Rutgers Cancer Institute of New Jersey
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Oncogenic Ras promotes glucose fermentation and glutamine use to supply central carbon metabolism, but how and why have only emerged recently. Ras-mediated metabolic reprogramming generates building blocks for growth and promotes antioxidant defense. To fuel metabolic pathways, Ras scavenges extracellular proteins and lipids. To bolster metabolism and mitigate stress, Ras activates cellular self-cannibalization and recycling of proteins and organelles by autophagy. Targeting these distinct features of Ras-driven cancers provides novel approaches to cancer therapy.
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