Journal
GENES & DEVELOPMENT
Volume 27, Issue 3, Pages 227-233Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.213306.113
Keywords
DNA replication; cell cycle checkpoint; 9-1-1; ATR; ATM
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Funding
- NIH [GM076388]
- MGH/NCI Proton Program
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The yeast Mec1 kinase is a key regulator of the DNA damage response (DDR). In this issue of Genes & Development, Kumar and Burgers (pp. 313-321) report that Ddc1, Dpb11, and Dna2 function in concert to activate Mec1 during S phase of the cell cycle. Furthermore, the Tel1 kinase also contributes to the DDR in S phase when Mec1 activation is compromised.
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