Journal
GENES & DEVELOPMENT
Volume 27, Issue 9, Pages 991-996Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.211243.112
Keywords
dendritic transport; DHX36; precursor-microRNA; protein synthesis; synaptic plasticity
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Funding
- DFG [SFB593]
- EMBO Young Investigator Program
- Austrian Academy of Sciences
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SpecificmicroRNAs (miRNAs), includingmiR-134, localize to neuronal dendrites, where they control synaptic protein synthesis and plasticity. However, the mechanism of miRNA transport is unknown. We found that the neuronal precursor-miRNA-134 (pre-miR-134) accumulates in dendrites of hippocampal neurons and at synapses in vivo. Dendritic localization of pre-miR-134 is mediated by the DEAH-box helicase DHX36, which directly associates with the pre-miR-134 terminal loop. DHX36 function is required for miR-134-dependent inhibition of target gene expression and the control of dendritic spine size. Dendritically localized pre-miR-134 could provide a local source of miR-134 that can be mobilized in an activity-dependent manner during plasticity.
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