Journal
GENES & DEVELOPMENT
Volume 27, Issue 4, Pages 351-354Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.214189.113
Keywords
C. elegans; fasting; lipid; autophagy; polyunsaturated fatty acids (PUFA); longevity
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Funding
- Howard Hughes Medical Institute Funding Source: Medline
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The health benefits of specific fatty acids and physiological roles of fat metabolism are important subjects that are still poorly understood. In this issue of Genes & Development, O'Rourke and colleagues (pp. 429-440) uncovered a role for lipase-generated omega-6 fatty acids in promoting autophagy and, consequently, life span extension under both fed and fasting conditions. The impact of this finding is discussed with regard to the nutritional value of omega-6 fatty acids and regulatory functions of fat metabolism beyond its well-known role in energy storage.
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