Journal
GENES & DEVELOPMENT
Volume 26, Issue 9, Pages 891-907Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.188326.112
Keywords
Rett syndrome; astrocyte; development; disease; heterogeneity; neurodevelopment; neuropsychiatric
Categories
Funding
- NINDS [NS059893]
- MRC [G0800575] Funding Source: UKRI
- Medical Research Council [G0800575] Funding Source: researchfish
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Astrocytes are no longer seen as a homogenous population of cells. In fact, recent studies indicate that astrocytes are morphologically and functionally diverse and play critical roles in neurodevelopmental diseases such as Rett syndrome and fragile X mental retardation. This review summarizes recent advances in astrocyte development, including the role of neural tube patterning in specification and developmental functions of astrocytes during synaptogenesis. We propose here that a precise understanding of astrocyte development is critical to defining heterogeneity and could lead advances in understanding and treating a variety of neuropsychiatric diseases.
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