Journal
GENES & DEVELOPMENT
Volume 26, Issue 8, Pages 751-755Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.191163.112
Keywords
T-ALL; EZH2; PRC2; leukemia; JARID2; DNMT3A
Categories
Funding
- Federal Share of the Program Income
- Massachusetts General Hospital [C06 CA059267]
- Proton Therapy Research and Treatment Center
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In the April 1, 2012, issue of Genes & Development, Simon and colleagues (pp. 651-656) demonstrated that the disruption of Ezh2 in mice is sufficient to cause T-acute lymphoblastic leukemia (T-ALL). Moreover, in concert with concurrent studies, the authors revealed that similar mechanisms are involved in human T-ALL. These data contrast with previous findings showing that increased EZH2 activity promotes cancer.
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