Journal
GENES & DEVELOPMENT
Volume 26, Issue 15, Pages 1685-1690Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.193433.112
Keywords
KNOX transcription factors; chromatin immunoprecipitation; gene regulation; maize
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Funding
- NSF [DBI-0604923, DBI-0701405, IOS-1125620]
- ARS [5335-21000-013-00D]
- NIH [5T32CA106196-05]
- Division Of Integrative Organismal Systems
- Direct For Biological Sciences [1125620] Funding Source: National Science Foundation
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KNOTTED1 (KN1)-like homeobox (KNOX) transcription factors function in plant meristems, self-renewing structures consisting of stem cells and their immediate daughters. We defined the KN1 cistrome in maize inflorescences and found that KN1 binds to several thousand loci, including 643 genes that are modulated in one or multiple tissues. These KN1 direct targets are strongly enriched for transcription factors (including other homeobox genes) and genes participating in hormonal pathways, most significantly auxin, demonstrating that KN1 plays a key role in orchestrating the upper levels of a hierarchical gene regulatory network that impacts plant meristem identity and function.
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