Journal
GENES & DEVELOPMENT
Volume 26, Issue 18, Pages 2001-2008Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.200006.112
Keywords
aging; peroxiredoxin; gerontogenes; genome instability; cancer; chemotherapy
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Funding
- Swedish Cancer Foundation
- Knut and Alice Wallenberg Foundation (Wallenberg Scholar Award)
- Advanced ERC grant (QualiAGE)
- Science Faculty at the University of Gothenburg
- Swedish Research Council (VR)
- Foundation of Olle Engkvist byggmastare
- Carl Trygger Foundation
- Magnus Bergvall Foundation
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Age is the highest risk factor known for a large number of maladies, including cancers. However, it is unclear how aging mechanistically predisposes the organism to such diseases and which gene products are the primary targets of the aging process. Recent studies suggest that peroxiredoxins, antioxidant enzymes preventing tumor development, are targets of age-related deterioration and that bolstering their activity (e.g., by caloric restriction) extends cellular life span. This review focuses on how the peroxiredoxin functions (i.e., as peroxidases, signal transducers, and molecular chaperones) fit with contemporary theories of aging and whether peroxiredoxins could be targeted therapeutically in the treatment of age-associated cancers.
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