4.7 Article

RNAi in fission yeast finds new targets and new ways of targeting at the nuclear periphery

Journal

GENES & DEVELOPMENT
Volume 26, Issue 8, Pages 741-745

Publisher

COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.191155.112

Keywords

RNAi; CTGS; NPC; stress response; thermoswitch; Atf1 transcription factor

Funding

  1. National Institutes of Health
  2. National Science Foundation

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RNAi in Schizosaccharomyces pombe is critical for centromeric heterochromatin formation. It has remained unclear, however, whether RNAi also regulates the expression of protein-coding loci. In the April 1, 2012, issue of Genes & Development, Woolcock and colleagues (pp. 683-667) reported an elegant mechanism for the conditional RNAi-mediated repression of stress response genes involving association with Dcr1 at the nuclear pore. Unexpectedly, the initial targeting of RNAi components to these genes does not require small RNA guides.

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