Journal
GENES & DEVELOPMENT
Volume 26, Issue 15, Pages 1648-1652Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.199059.112
Keywords
telomere; telomerase; t-circle; Arabidopsis; recombination; Ku
Categories
Funding
- NIH [R01-GM065383]
- NSF [MCB-1052018]
- Div Of Molecular and Cellular Bioscience
- Direct For Biological Sciences [1052018] Funding Source: National Science Foundation
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Telomeres ensure the complete replication of genetic material while simultaneously distinguishing the chromosome terminus from a double-strand break. A prevailing theme in telomere biology is that the two chromosome ends are symmetrical. Both terminate in a single-strand 3' extension, and the 3' extension is crucial for telomere end protection. In this issue of Genes & Development, Kazda and colleagues (pp. 1703-1713) challenge this paradigm using a series of elegant biochemical and genetic assays to demonstrate that half of the chromosomes in flowering plants are blunt-ended. This discovery reveals unanticipated complexity in telomeric DNA processing and a novel mode of chromosome end protection.
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