Journal
GENES & DEVELOPMENT
Volume 26, Issue 10, Pages 1022-1027Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.189514.112
Keywords
RNase P; tRNA maturation; RNA processing; pentatricopeptide repeat; plant
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Funding
- French Centre National de la Recherche Scientifique.''
- ANR [ANR 11 BSV8 008 01]
- LabEx consortium
- University of Strasbourg
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RNase P is an essential enzyme that cleaves the 59 leader sequence of tRNA precursors. RNase Ps were believed until now to occur universally as ribonucleoproteins in organisms performing RNase P activity. Here we find that protein-only RNase P enzymes called PRORP (for proteinaceous RNase P) support RNase P activity in vivo in both organelles and the nucleus in Arabidopsis. Beyond tRNA, PRORP proteins are involved in the maturation of small nucleolar RNA (snoRNA) and mRNA. Finally, ribonucleoprotein RNase MRP is not involved in tRNA maturation in plants. Altogether, our results indicate that ribonucleoprotein enzymes have been entirely replaced by proteins for RNase P activity in plants.
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