Journal
GENES & DEVELOPMENT
Volume 25, Issue 8, Pages 789-794Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.2027911
Keywords
Polycomb; Ezh2; satellite cells; muscle growth; muscle regeneration
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Funding
- NH and MRC (Australia)
- National Institute of Arthritis, Musculoskeletal, and Skin Diseases of the National Institutes of Health
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Satellite cells (SCs) sustain muscle growth and empower adult skeletal muscle with vigorous regenerative abilities. Here, we report that EZH2, the enzymatic subunit of the Polycomb-repressive complex 2 (PRC2), is expressed in both Pax7(+)/Myf5(-) stem cells and Pax7(+)/Myf5(+) committed myogenic precursors and is required for homeostasis of the adult SC pool. Mice with conditional ablation of Ezh2 in SCs have fewer muscle postnatal Pax7(+) cells and reduced muscle mass and fail to appropriately regenerate. These defects are associated with impaired SC proliferation and derepression of genes expressed in nonmuscle cell lineages. Thus, EZH2 controls self-renewal and proliferation, and maintains an appropriate transcriptional program in SCs.
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