Journal
GENES & DEVELOPMENT
Volume 25, Issue 2, Pages 101-106Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.2018811
Keywords
ChIP-seq; NF-kB; Pu.1; chromatin; inflammation; macrophages
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Funding
- EC
- Italian Association for Research on Cancer (AIRC)
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Inflammation involves the activation of a highly co-ordinated gene expression program that is specific for the initial stimulus and occurs in a different manner in bystander parenchymal cells and professional immune system cells recruited to the inflamed site. Recent data demonstrate that developmental transcription factors like the macrophage fate-determining Pu.1 set the stage for the activity of ubiquitous transcription factors activated by inflammatory stimuli, like NF-kB, AP-1, and interferon regulatory factors (IRFs). The intersection of lineage-determining and stimulus-activated transcription factors at enhancers explains cell type specificity in inflammatory responses.
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