Journal
GENES & DEVELOPMENT
Volume 25, Issue 3, Pages 226-231Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.1974211
Keywords
miR-335; metastasis; genetic; tumor intiation; ovarian; epigenetic
Categories
Funding
- Rita Allen
- Anderson Cancer Center
- Sidney Kimmel
- ASCO
- Meyer
- Sinsheimer
- Emerald foundations
- Breast Cancer Alliance
- Hess family
- DOD
- National Institutes of Health
- Hearst Foundation
- Kleberg Foundation
Ask authors/readers for more resources
Post-transcriptional regulators have emerged as robust effectors of metastasis and display deregulated expression through unknown mechanisms. Here, we reveal that the human microRNA-335 locus undergoes genetic deletion and epigenetic promoter hypermethylation in every metastatic derivative obtained from independent patients' malignant cell populations. Genetic deletion of miR-335 is a common event in human breast cancer, is enriched for in breast cancer metastases, and also correlates with ovarian cancer recurrence. We furthermore identify miR-335 as a robust inhibitor of tumor reinitiation. We thus implicate the miR-335 locus on 7q32.2 as the first selective metastasis suppressor and tumor initiation suppressor locus in human breast cancer.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available