Journal
GENES & DEVELOPMENT
Volume 25, Issue 14, Pages 1464-1469Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.2060311
Keywords
Xenopus egg extracts; chromosome condensation; cohesin; condensins; sister chromatid cohesion
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Funding
- [20002010]
- Grants-in-Aid for Scientific Research [22770201, 20002010] Funding Source: KAKEN
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To understand how chromosome shapes are determined by actions of condensins and cohesin, we devised a series of protocols in which their levels are precisely changed in Xenopus egg extracts. When the relative ratio of condensin I to II is forced to be smaller, embryonic chromosomes become shorter and thicker, being reminiscent of somatic chromosomes. Further depletion of condensin II unveils its contribution to axial shortening of chromosomes. Cohesin helps juxtapose sister chromatid arms by collaborating with condensin I and counteracting condensin II. Thus, chromosome shaping is achieved by an exquisite balance among condensin I and II and cohesin.
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