Journal
GENES & DEVELOPMENT
Volume 25, Issue 2, Pages 131-136Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.610511
Keywords
Drosophila; morphogen; shape; proliferation; growth; tension; computational modeling
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Funding
- Cancer Research UK
- Medical Research Council (MRC) [G0802456]
- Cancer Research UK [10748] Funding Source: researchfish
- Medical Research Council [G0802456] Funding Source: researchfish
- MRC [G0802456] Funding Source: UKRI
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Tissues can grow in a particular direction by controlling the orientation of cell divisions. This phenomenon is evident in the developing Drosophila wing epithelium, where the tissue becomes elongated along the proximal-distal axis. We show that orientation of cell divisions in the wing requires planar polarization of an atypical myosin, Dachs. Our evidence suggests that Dachs constricts cell-cell junctions to alter the geometry of cell shapes at the apical surface, and that cell shape then determines the orientation of the mitotic spindle. Using a computational model of a growing epithelium, we show that polarized cell tension is sufficient to orient cell shapes, cell divisions, and tissue growth. Planar polarization of Dachs is ultimately oriented by long-range gradients emanating from compartment boundaries, and is therefore a mechanism linking these gradients with the control of tissue shape.
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