Journal
GENES & DEVELOPMENT
Volume 25, Issue 15, Pages 1583-1588Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.16985411
Keywords
polycomb; enhancer; chromatin; CpG islands
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Funding
- Medical Research Council
- National Institute for Health Research (NIHR) Biomedical Research Centre
- Medical Research Council [MC_EX_G0701347, G1000801b, G0700711B] Funding Source: researchfish
- MRC [MC_EX_G0701347] Funding Source: UKRI
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Remote distal enhancers may be located tens or thousands of kilobases away from their promoters. How they control gene expression is still poorly understood. Here, we analyze the influence of a remote enhancer on the balance between repression (Polycomb-PcG) and activation (Trithorax-TrxG) of a developmentally regulated gene associated with a CpG island. We reveal its essential, nonredundant role in clearing the PcG complex and H3K27me3 from the CpG island. In the absence of the enhancer, the H3K27me3 demethylase (JMJD3) is not recruited to the CpG island. We propose a new role of long-range regulatory elements in removing repressive PcG complexes.
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