Journal
GENES & DEVELOPMENT
Volume 25, Issue 24, Pages 2555-2558Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.183020.111
Keywords
long noncoding RNA; erythroid terminal differentiation; apoptosis
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Funding
- Roche Foundation for Anemia Research (RoFAR)
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Long noncoding RNAs (lncRNAs) are a large and diverse class of functional RNAs that regulate important biological processes, including cell division, survival, and differentiation. In this issue of Genes & Development, Hu and colleagues (2573-2578) report the discovery of LincRNA erythroid prosurvival (LincRNA-EPS), a murine lncRNA that facilitates red blood cell formation (erythropoiesis) by suppressing apoptosis. This finding expands the repertoire of lncRNA functions and illustrates a novel genetic pathway that potentially can be exploited for treating anemias.
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