Journal
GENES & DEVELOPMENT
Volume 25, Issue 23, Pages 2423-2428Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.181487.111
Keywords
lineage formation; neural development; neural stem cells; Sox genes
Categories
Funding
- IZKF Erlangen
- Deutsche Forschungsgemeinschaft
- ForNeuroCell 2
- Fonds der Chemischen Industrie
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Vertebrate embryonic stem (ES) cells give rise to many different cell types in multistep processes. These involve the establishment of a competent state, specification, differentiation, and maturation, and often involve Sox transcription factors. In this issue of Genes & Development, Bergsland and colleagues (pp. 2453-2464) determine the genome-wide binding profile of Sox2, Sox3, and Sox11 as ES cells become specified to neural precursors and differentiate into neurons. An ordered, sequential binding of these Sox proteins to a common set of gene enhancers was found to drive neurogenesis, as Sox proteins first help to preselect neural genes in ES cells and later ensure their proper activation in neural precursors or neurons.
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