Journal
GENES & DEVELOPMENT
Volume 24, Issue 17, Pages 1893-1902Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.1945010
Keywords
Lipid rafts; biofilm formation; Flotillin-1; bacteria; Bacillus subtilis; Staphylococcus aureus
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Funding
- NIH [GM58213]
- Fundacion Seneca, Comunidad Autonoma de la Region de Murcia (Spain)
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The membranes of eukaryotic cells harbor microdomains known as lipid rafts that contain a variety of signaling and transport proteins. Here we show that bacterial membranes contain microdomains functionally similar to those of eukaryotic cells. These membrane microdomains from diverse bacteria harbor homologs of Flotillin-1, a eukaryotic protein found exclusively in lipid rafts, along with proteins involved in signaling and transport. Inhibition of lipid raft formation through the action of zaragozic acid-a known inhibitor of squalene synthases-impaired biofilm formation and protein secretion but not cell viability. The orchestration of physiological processes in microdomains may be a more widespread feature of membranes than previously appreciated.
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