Journal
GENES & DEVELOPMENT
Volume 24, Issue 21, Pages 2365-2382Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.1953710
Keywords
C. elegans; Drosophila; TRP; cGMP; thermosensory; thermotaxis
Categories
Funding
- NIH [PO1 NS044232, R21 NS061147, DP1 OD004064, RO1 GM081639]
- NSF [0725079, 1025307]
- Direct For Biological Sciences
- Division Of Integrative Organismal Systems [1025307] Funding Source: National Science Foundation
- Division Of Integrative Organismal Systems
- Direct For Biological Sciences [0725079] Funding Source: National Science Foundation
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Like other ectotherms, the roundworm Caenorhabditis elegans and the fruit fly Drosophila melanogaster rely on behavioral strategies to stabilize their body temperature. Both animals use specialized sensory neurons to detect small changes in temperature, and the activity of these thermosensors governs the neural circuits that control migration and accumulation at preferred temperatures. Despite these similarities, the underlying molecular, neuronal, and computational mechanisms responsible for thermotaxis are distinct in these organisms. Here, we discuss the role of thermosensation in the development and survival of C. elegans and Drosophila, and review the behavioral strategies, neuronal circuits, and molecular networks responsible for thermotaxis behavior.
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