Journal
GENES & DEVELOPMENT
Volume 24, Issue 15, Pages 1580-1589Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.1941710
Keywords
Mdm2; tumorigenesis; p53; oncogene; tumor suppressor; ubiquitination
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Funding
- National Cancer Institute [P01 CA080058, R01 CA125741, R01 CA086001]
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Mdm2 has been well characterized as a negative regulator of the tumor suppressor p53. Recent studies have shown that Mdm2 is activated in response to a variety of oncogenic pathways independent of p53. Although its role as an oncogene via suppression of p53 function remains clear, growing evidence argues for p53-independent effects, as well as the remarkable possibility that Mdm2 has tumor suppressor functions in the appropriate context. Hence, Mdm2 is proving to be a key player in human cancer in its own right, and thus an important target for therapeutic intervention.
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