Journal
GENES & DEVELOPMENT
Volume 24, Issue 17, Pages 1827-1831Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.1972810
Keywords
mRNA; localization; yeast; She2p; Spt4p; Spt5p; cotranscriptional
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Funding
- NIH [GM57071]
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She2p is an RNA-binding protein that recognizes a zipcode on specific mRNAs necessary for the assembly of a protein complex that localizes them to the yeast bud tip. In this issue of Genes & Development, Shen and colleagues (pp. 1914-1926) demonstrate that She2p associates with RNAPII globally, but then recognizes the nascent chain only if it contains a zipcode. This demonstrates yet another case where the mRNA's cytoplasmic fate is determined by the RNAPII complex.
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