Journal
GENES & DEVELOPMENT
Volume 24, Issue 10, Pages 986-991Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.579910
Keywords
RNA silencing; Arabidopsis; siRNAs; chromatin; histone demethylase
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Funding
- Gatsby Charitable Foundation
- EU [LSHG-CT-2006-037900]
- Edward Mallinckrodt Jr. Foundation
- Marie Curie Incoming International post-doctoral fellowship
- Wellcome Trust
- Commonwealth and NSERC
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JMJ14 is a histone H3 Lys4 (H3K4) trimethyl demethylase that affects mobile RNA silencing in an Arabidopsis transgene system. It also influences CHH DNA methylation, abundance of endogenous transposon transcripts, and flowering time. JMJ14 acts at a point in RNA silencing pathways that is downstream from RNA-dependent RNA polymerase 2 (RDR2) and Argonaute 4 (AGO4). Our results illustrate a link between RNA silencing and demethylation of histone H3 trimethylysine. We propose that JMJ14 acts downstream from the Argonaute effector complex to demethylate histone H3K4 at the target of RNA silencing.
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