Journal
GENES & DEVELOPMENT
Volume 24, Issue 24, Pages 2723-2731Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.1976710
Keywords
Cohesin; DNA replication; sister chromatid cohesion; chromosome; mitosis; cell cycle
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Funding
- National Institutes of Health [GM094972]
- American Cancer Society [CCG114520]
- Ministry of Education, Science, Sports, and Culture of Japan
- Sumitomo Foundation
- Uehara Memorial foundation
- Naito Foundation
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The ring-shaped cohesin complex links sister chromatids and plays crucial roles in homologous recombination and mitotic chromosome segregation. In cycling cells, cohesin's ability to generate cohesive linkages is restricted to S phase and depends on loading and establishment factors that are intimately connected to DNA replication. Here we review how cohesin is regulated by the replication machinery, as well as recent evidence that cohesin itself influences how chromosomes are replicated.
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