Journal
GENES & DEVELOPMENT
Volume 24, Issue 2, Pages 111-114Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.1893610
Keywords
p53; RNA polymerase II; transcription; core promoters; p21; Fas/APO1; NF-Y
Categories
Funding
- NIH [CA117907]
- NSF [MCB-0842974]
Ask authors/readers for more resources
p53 is a pleiotropic transcription factor driving a flexible transcriptional program that mediates disparate cellular responses to stress, including cell cycle arrest and apoptosis. The mechanisms by which p53 differentially regulates its diverse target genes remain poorly understood. In this issue of Genes & Development, Morachis and colleagues (pp. 135-147) demonstrate the critical role of core promoter elements at p53 target loci, in that they dictate differential RNA polymerase II recruitment and activity in a p53-autonomous fashion.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available