Journal
GENES & DEVELOPMENT
Volume 23, Issue 14, Pages 1601-1605Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.1824909
Keywords
DNA methylation; epigenetics; epigenome maps; methylation profiling
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Funding
- National Science Foundation [MCB-0548597]
- National Institutes of Health [R01GM078256]
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Two recent reports, including one by Reinders and colleagues (pp. 939-950) in the April 15, 2009, issue of Genes & Development, describe the construction of Arabidopsis recombinant inbred populations that maximize epigenetic rather than genetic variation. The distribution and behavior of phenotypic variation in these populations suggest that stable epialleles can control complex quantitative traits. However, stochastic epimutation and transposon movement in these populations present some unexpected technical hurdles to implementing quantitative epigenetic analysis.
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