Journal
GENES & DEVELOPMENT
Volume 23, Issue 5, Pages 549-554Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.1770009
Keywords
Small RNA; miRNA; Arabidopsis; leaf; polarity; pattern fomation
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Funding
- USDA [2006-03420, 2006-35301-17420]
- NSF [IOB-0615721, MCB-0618433]
- NIH [AI43288]
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MicroRNAs and trans-acting siRNAs (ta-siRNAs) have important regulatory roles in development. Unlike other developmentally important regulatory molecules, small RNAs are not known to act as mobile signals during development. Here, we show that low-abundant, conserved ta-siRNAs, termed tasiR-ARFs, move intercellularly from their defined source of biogenesis on the upper (adaxial) side of leaves to the lower (abaxial) side to create a gradient of small RNAs that patterns the abaxial determinant AUXIN RESPONSE FACTOR3. Our observations have important ramifications for the function of small RNAs and suggest they can serve as mobile, instructive signals during development.
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