Journal
GENES & DEVELOPMENT
Volume 23, Issue 22, Pages 2598-2603Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.552109
Keywords
Transvection; imprinting; epigenetics; replication timing; H19 ICR
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Funding
- Swedish Science Research Council
- Swedish Cancer Research Foundation
- Swedish Pediatric Cancer Foundation
- Lundberg Foundation
- HEROIC
- ChILL (EU integrated projects)
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Recent observations highlight that the mammalian genome extensively communicates with itself via long-range chromatin interactions. The causal link between such chromatin cross-talk and epigenetic states is, however, poorly understood. We identify here a network of physically juxtaposed regions from the entire genome with the common denominator of being genomically imprinted. Moreover, CTCF-binding sites within the H19 imprinting control region (ICR) not only determine the physical proximity among imprinted domains, but also transvect allele-specific epigenetic states, identified by replication timing patterns, to interacting, nonallelic imprinted regions during germline development. We conclude that one locus can directly or indirectly pleiotropically influence epigenetic states of multiple regions on other chromosomes with which it interacts.
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