Journal
GENES & DEVELOPMENT
Volume 23, Issue 19, Pages 2278-2283Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.535409
Keywords
ILK; vascular wall formation; unitary layer; vascular smooth muscle cells (VSMCs); contractility; ROCK
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Funding
- Cancer Research UK
- Collaborative Research Centre 492 of the DFG
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Vascular smooth muscle cells (VSMCs) form contractile layers around larger blood vessels in a process that is essential for the formation of a fully functional vasculature. Here, we show that integrin-linked kinase (ILK) is required for the formation of a unitary layer of aligned VSMCs around arterioles and the regulation of blood vessel constriction in mice. In the absence of ILK, activated Rho/ROCK signaling induces the elevated phosphorylation of myosin light chain leading to abnormally enhanced VSMC contraction in vitro and in vivo. Our findings identify ILK as a key component regulating vascular wall formation by negatively modulating VSMC contractility.
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