Journal
GENES & DEVELOPMENT
Volume 23, Issue 7, Pages 788-797Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.1779209
Keywords
PRDM16; FoxC2; brown fat; UCP1; PGC-1 alpha; obesity
Categories
Funding
- NIH [DK081605]
- Japan Society for the Promotion of Science
- Picower foundation
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The last several years have seen an explosion of information relating to the transcriptional control of brown fat cell development. At the same time, new data have emerged that clearly demonstrate that adult humans do indeed have substantial amounts of functioning brown adipose tissue ( BAT). Together, these advances are stimulating a reassessment of the role of brown adipose tissue in human physiology and pathophysiology. These data have also opened up exciting new opportunities for the development of entirely novel classes of therapeutics for metabolic diseases like obesity and type 2 diabetes.
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