Journal
GENES & DEVELOPMENT
Volume 23, Issue 13, Pages 1487-1493Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.1824009
Keywords
Oligodendrocyte; CNS development; Wnt; multiple sclerosis; remyelination; Olig2
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Funding
- National Multiple Sclerosis Society Career Transition [TA 3008A2/T]
- NIH/NINDS [NS062796-01]
- NIH CBM Predoctoral Training
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Balancing extrinsic and intrinsic cues plays an integral part in shaping the complex architecture of the nervous system. During development, oligodendrocyte precursor cells integrate environmental signals and coordinate the activation of the transcriptional machinery necessary for differentiation and myelination. In this issue of Genes & Development, Fancy and colleagues (pp. 1571-1585) demonstrate that canonical Wnt signaling contributes to the decision of an oligodendrocyte precursor cell to differentiate-both during development and after demyelination. These findings provide new insight into the precise spatiotemporal coordination required for oligodendrocyte development.
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