Journal
GENES & DEVELOPMENT
Volume 22, Issue 17, Pages 2291-2296Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.1715208
Keywords
centrosomes; mitosis; actin; adhesion; cancer; cell cycle
Categories
Funding
- Cancer Research UK
- CNRS [UMR 144]
- FRM
- Institut Curie
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Cells with extra centrosomes rely entirely on centrosome clustering mechanisms to assemble a bipolar spindle and to divide in a bipolar fashion. To identify the pathways involved in suppression of multipolarity, Kwon, Godinho, and colleagues ( pp. 2189-2203) have set up a genome-wide screen in Drosophila S2 cells. Surprisingly, they found that efficient clustering requires a large number of proteins associated with a variety of cellular functions.
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