Journal
GENES & DEVELOPMENT
Volume 22, Issue 11, Pages 1416-1421Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.1685108
Keywords
ATR; ATRIP; TopBP1; checkpoint; PIKK; Ddc2
Categories
Funding
- Howard Hughes Medical Institute Funding Source: Medline
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In this issue of Genes & Development, Mordes and colleagues (pp. 1478-1489) reveal intriguing mechanistic insights into activation of the ATR (ATM and Rad3-related) kinase critical for DNA damage resistance. They identify conserved regulatory domains within ATR and its binding partner ATRIP (ATR-interacting protein), which are contacted by the ATR activator TopBP1. These discoveries expand on our understanding of the regulation of other PIKK family members, which also contain these domains, and illustrate how functional diversity has been achieved among these kinases.
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