Journal
GENES & DEVELOPMENT
Volume 22, Issue 23, Pages 3227-3231Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.1753508
Keywords
microRNA; heart development; serum response factor; myocyte enhancer factor-2; cyclin D2
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Funding
- NIH [5R01HL49579, 5R01DK55383, 1RO1HL63206]
- Deutsche Forschungsgemeinschaft (DFG) [Ro2173/1-1, Ro2173/2-1]
- Bundesministerium fur Bildung und Forschung [01GS0108, 01GS0420]
- NGFNplus
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MicroRNAs play an essential role in diverse cellular processes, such as proliferation, differentiation, apoptosis, and stress response. Recent studies demonstrate that miRNAs are important for timing developmental decisions and fine-tuning cellular determination in vertebrate heart development. In an elegant set of experiments reported in this issue of Genes & Development, Liu et al. (pp. 3242-3254) demonstrate that miR-133a functions as an inhibitor of cardiomyocyte proliferation and a modifier of serum response factor (SRF)-dependent transcriptional signaling in the murine heart. Both targeted deletion and transgenic overexpression of miR-133a can result in the same cardiac phenotype, ventricular septal defect (VSD) and heart failure. The new data add another piece to the puzzle of regulatory networks that are implicated in cardiac disease. It will be interesting to see, if miR-133a is also involved in human heart diseases, especially VSD and dilated cardiomyopathy.
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