Journal
GENES & DEVELOPMENT
Volume 22, Issue 1, Pages 8-13Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.1613108
Keywords
Drosophila; miR-iab-4; Hox; antisense miRNAs
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Funding
- NATIONAL HUMAN GENOME RESEARCH INSTITUTE [R01HG004037] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM067031] Funding Source: NIH RePORTER
- NHGRI NIH HHS [R01 HG004037, R01 HG004037-01A1] Funding Source: Medline
- NIGMS NIH HHS [R01 GM067031] Funding Source: Medline
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MicroRNAs (miRNAs) are similar to 22-nucleotide RNAs that are processed from characteristic precursor hairpins and pair to sites in messages of protein-coding genes to direct post-transcriptional repression. Here, we report that the miRNA iab-4 locus in the Drosophila Hox cluster is transcribed convergently from both DNA strands, giving rise to two distinct functional miRNAs. Both sense and antisense miRNA products target neighboring Hox genes via highly conserved sites, leading to homeotic transformations when ectopically expressed. We also report sense/antisense miRNAs in mouse and find antisense transcripts close to many miRNAs in both flies and mammals, suggesting that additional sense/antisense pairs exist.
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