Journal
GENES & DEVELOPMENT
Volume 22, Issue 18, Pages 2473-2478Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.479308
Keywords
adult neurogenesis; Tlx; self-renewal; subventricular zone
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Funding
- Deutsche Forschungsgemeinschaft [SFB 488, SFB 636]
- European Union [LSHM-CT-2005-018652]
- Fonds der Chemischen Industrie
- Bundesministerium fur Bildung und Forschung (BMBF)
- NGFN [FZK 01GS01117, 01GS0477, KGCV1/01GS0416]
- [FOR Ot 165/2-2]
- [GRK 791/1.02]
- [0313074C]
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The tailless (Tlx) gene encodes an orphan nuclear receptor that is expressed by neural stem/progenitor cells in the adult brain of the subventricular zone (SVZ) and the dentate gyrus (DG). The function of Tlx in neural stem cells of the adult SVZ remains largely unknown. We show here that in the SVZ of the adult brain Tlx is exclusively expressed in astrocyte-like B cells. An inducible mutation of the Tlx gene in the adult brain leads to complete loss of SVZ neurogenesis. Furthermore, analysis indicates that Tlx is required for the transition from radial glial cells to astrocyte-like neural stem cells. These findings demonstrate the crucial role of Tlx in the generation and maintenance of NSCs in the adult SVZ in vivo.
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