Journal
GENES & DEVELOPMENT
Volume 22, Issue 18, Pages 2479-2484Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.475408
Keywords
eomesodermin; Tbr2; neuronal progenitor cells; SVZ; brain size
Categories
Funding
- Wellcome Trust Programme
- Alexander von Humboldt-Foundation, Germany [BBSRC-BB/F003285/1]
- MRC [G0300200]
- Biotechnology and Biological Sciences Research Council [BB/F003285/1] Funding Source: researchfish
- Medical Research Council [G0300200] Funding Source: researchfish
- BBSRC [BB/F003285/1] Funding Source: UKRI
- MRC [G0300200] Funding Source: UKRI
Ask authors/readers for more resources
The embryonic subventricular zone (SVZ) is a critical site for generating cortical projection neurons; however, molecular mechanisms regulating neurogenesis specifically in the SVZ are largely unknown. The transcription factor Eomes/Tbr2 is transiently expressed in cortical SVZ progenitor cells. Here we demonstrate that conditional inactivation of Tbr2 during early brain development causes microcephaly and severe behavioral deficits. In Tbr2 mutants the number of SVZ progenitor cells is reduced and the differentiation of upper cortical layer neurons is disturbed. Neurogenesis in the adult dentate gyrus but not the subependymal zone is abolished. These studies establish Tbr2 as a key regulator of neurogenesis in the SVZ.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available