Journal
GENES & DEVELOPMENT
Volume 22, Issue 21, Pages 2914-2925Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.1717808
Keywords
Small RNA; noncoding RNA; Hfq; RNase E; sugar; polyadenylation
Categories
Funding
- Deutsche Forschungsgemeinschaft
- DFG [SPP1258]
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Noncoding RNA regulators have been implicated in almost all imaginable cellular processes. Here we review how regulatory small RNAs such as Spot42, SgrS, GlmY, and GlmZ and a cis-encoded ribozyme in glmS mRNA control sugar metabolism. Besides discussing the physiological implications, we show how the study of these molecules contributed to our understanding of the mechanisms and of general principles of RNA-based regulation. These include the post-transcriptional repression or activation of gene expression within polycistronic mRNAs; novel ribonucleoprotein complexes composed of small RNA, Hfq, and/or RNase E; and the hierarchical action of regulatory RNAs.
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